Parkinson’s Disease Psychosis

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Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson’s disease

By Philippe Huot MD, PhD, FRCPC, DABPN, Tom H. Johnston PhD, Naomi P. Visanji PhD, Tayyeba Darr BSc, Donna Pires RVT, Lili-Naz Hazrati MD, PhD, FRCPC, Jonathan M. Brotchie PhD andSusan H. Fox MB ChB, MRCP(UK), PhD

Visual hallucinations are common in advanced Parkinson’s disease (PD). The pathophysiology of visual hallucinations may involve enhanced serotonergic neurotransmission. The atypical antipsychotics clozapine and quetiapine, which have affinity for 5-HT(2A) and 5-HT(1A) receptors, are effective against visual hallucinations in PD. 5-HT(2A) receptors are increased in ventral visual pathways in PD patients with visual hallucinations, and…

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Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations

By Philippe Huot MD, MSc, FRCPC, DABPN, Tom H. Johnston PhD, Tayyeba Darr BSc, Lili-Naz Hazrati MD, PhD, FRCPC, Naomi P. Visanji PhD, Donna Pires RVT, Jonathan M. Brotchie PhD and Susan H. Fox MRCP(UK), PhD

Well-formed visual hallucinations (VH) are common in patients with Parkinson’s disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5-HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5-HT2A receptor levels may…

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