psychosis

“String Hallucinations”: Multimodal Tactile and Visual Hallucinations in Parkinson’s Disease

By Jesús Pérez-Pérez MD, Javier Pagonabarraga MD, PhD, Ramón Fernández-Bobadilla PhD and Jaime Kulisevsky MD, PhD

The aim of this work was to report on 7 patients presenting a distinctive form of multimodal (tactile and visual) hallucinations for which the term “string hallucinations” is proposed. Having observed a patient interacting with imaginary strips of skin in his hands at our movement disorders unit, we prospectively studied PD patients and caregivers over…

Psychosis in Parkinson’s disease without dementia: Common and comorbid with other non-motor symptoms

By Angela H. Lee BA and Daniel Weintraub MD

Psychosis in Parkinson’s disease (PD) is common and associated with a range of negative outcomes. Dementia and psychosis are highly correlated in PD, but the frequency and correlates of psychosis in patients without cognitive impairment are not well understood. One hundred and ninety-one non-demented PD patients at two movement disorders centers participated in a study…

Diagnostic criteria for psychosis in Parkinson’s disease: Report of an NINDS, NIMH work group

By Bernard Ravina MD, MSCE,*, Karen Marder MD, MPH, Hubert H. Fernandez MD, Joseph H. Friedman MD, William McDonald MD, Diane Murphy PhD, Dag Aarsland MD, Debra Babcock MD, PhD, Jefferey Cummings MD, Jean Endicott PhD, Stewart Factor MD, Wendy Galpern MD, PhD, Andrew Lees MD, Laura Marsh MD, Mark Stacy MD, Katrina Gwinn-Hardy MD, Valerie Voon MD and Christopher Goetz MD

There are no standardized diagnostic criteria for psychosis associated with Parkinson’s disease (PDPsy). As part of an NIH sponsored workshop, we reviewed the existing literature on PDPsy to provide criteria that distinguish PDPsy from other causes of psychosis. Based on these data, we propose provisional criteria for PDPsy in the style of the Diagnostic and…

Scales to assess psychosis in Parkinson’s disease: Critique and recommendations

By Hubert H. Fernandez MD, Dag Aarsland MD, Gilles Fénelon MD, Joseph H. Friedman MD, Laura Marsh MD, Alexander I. Tröster PhD, Werner Poewe MD, Olivier Rascol MD, Cristina Sampaio MD, Glenn T. Stebbins PhD and Christopher G. Goetz MD

Psychotic symptoms are a frequent occurrence in Parkinson’s disease (PD), affecting up to 50% of patients. The Movement Disorder Society established a Task Force on Rating Scales in PD, and this critique applies to published, peer-reviewed rating psychosis scales used in PD psychosis studies. Twelve psychosis scales/questionnaires were reviewed. None of the reviewed scales adequately…

The changing face of Parkinson’s disease-associated psychosis: A cross-sectional study based on the new NINDS-NIMH criteria

By Gilles Fénelon MD, PhD, Thierry Soulas MA, Franck Zenasni PhD and Laurent Cleret de Langavant MD

New criteria for Parkinson’s disease-associated psychosis (PDAP) were recently proposed by a NINDS-NIMH working group. We assessed 116 consecutive unselected outpatients with PD for the existence of psychotic symptoms during the previous month, using a structured questionnaire covering the whole spectrum of PDAP symptoms. Hallucinations occurred in 42% of the patients (visual: 16%; nonvisual: 35%),…

Disease-related and genetic correlates of psychotic symptoms in Parkinson’s disease

By Stewart A. Factor DO, N. Kyle Steenland PhD, Donald S. Higgins MD, Eric S. Molho MD, Denise M. Kay PhD, Jennifer Montimurro MS, Ami R. Rosen MS, CGC, Cyrus P. Zabetian MD and Haydeh Payami PhD

Our aim was to examine disease-related and genetic correlates of the development of psychotic symptoms in a large population of patients with Parkinson’s disease. We studied 500 patients with Parkinson’s disease from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/nonmotor features), and genetic, measured as continuous or dichotomous variables. Continuous…

psychosis

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