Parkinson’s Disease Psychosis

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dementia with Lewy bodies

Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: A 123I-FP-CIT SPECT study

By Francesco Roselli MD, Nicola M. Pisciotta MD, Robert Perneczky MD, Michele Pennelli MSc(Psych), Maria S. Aniello MD, Maria F. De Caro PhD, Ermanno Ferrannini MD, Bruno Tartaglione MD, Giovanni Defazio MD, PhD, Giuseppe Rubini MD and Paolo Livrea MD, PhD

Neuropsychiatric symptoms are frequent in dementia with Lewy bodies (DLB). Dopamine transporter (DAT) imaging with 123I-labeled ligand N-δ-(fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)tropene (123I-FP-CIT), which reliably measures midbrain dopaminergic dysfunction, has provided important evidence on the neurobiological substrate of some of these symptoms including apathy and depression. However, little is known on DAT levels and other distressing symptoms such as…

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Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies

By Akira Kurita MD, Maiko Murakami MD, Satoshi Takagi MD, Masato Matsushima MD and Masahiko Suzuki MD

Visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD), while auditory hallucinations are rare. To neurophysiologically investigate the pathophysiology of VHs in these disorders, we studied event-related potentials (ERPs) of DLB, PDD, and Alzheimer’s disease (AD) patients. We compared visual and auditory ERP latencies among PDD patients…

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