Parkinson’s Disease Psychosis

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Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations

By Philippe Huot MD, MSc, FRCPC, DABPN, Tom H. Johnston PhD, Tayyeba Darr BSc, Lili-Naz Hazrati MD, PhD, FRCPC, Naomi P. Visanji PhD, Donna Pires RVT, Jonathan M. Brotchie PhD and Susan H. Fox MRCP(UK), PhD

Well-formed visual hallucinations (VH) are common in patients with Parkinson’s disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5-HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5-HT2A receptor levels may…

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