Parkinson’s Disease Psychosis

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5-HT1A receptors

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson’s disease

By Philippe Huot MD, PhD, FRCPC, DABPN, Tom H. Johnston PhD, Naomi P. Visanji PhD, Tayyeba Darr BSc, Donna Pires RVT, Lili-Naz Hazrati MD, PhD, FRCPC, Jonathan M. Brotchie PhD andSusan H. Fox MB ChB, MRCP(UK), PhD

Visual hallucinations are common in advanced Parkinson’s disease (PD). The pathophysiology of visual hallucinations may involve enhanced serotonergic neurotransmission. The atypical antipsychotics clozapine and quetiapine, which have affinity for 5-HT(2A) and 5-HT(1A) receptors, are effective against visual hallucinations in PD. 5-HT(2A) receptors are increased in ventral visual pathways in PD patients with visual hallucinations, and…

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